Genome Analysis, a spin-off of Harokopio University, is a Greek company specializing in the field of genetics and preventive medicine.
It was founded in 2020 by Professor of Molecular Genetics and Nutrigenetics Georgios Dedoussis and internist Dimitris Dellis, with the vision of promoting and strengthening personalized prevention. Dedicated to the promotion of health and wellness, we offer innovative genetic analysis services with maximum predictive value, which are valuable clinical prognostic tools.
Genome Analysis has an exclusive license to use and exploit the know-how developed in the advanced laboratories of the Department of Dietetics – Nutrition Science of Harokopio University, in the fields of Molecular Nutrition and Genetics.
Polygenic Risk Scores
A person’s DNA, environment and lifestyle determine the course of their health. Early genetic analyses studied a small number of genetic variants (polymorphisms), usually up to 50. But as most traits and diseases are shaped by tens of thousands of polymorphisms, their predictive ability was low. With the development of genetics and the creation of Polygenic Risk Scores (PRS), the predictive value of genetic analyses increased, but they could not yet be used in clinical practice.
Genome Analysis PRSs analyse up to 900,000 genetic variants and are calculated using an innovative algorithm. Thus, we maximise the predictive accuracy of genetic analysis, creating a clinically important tool for early prediction and personalised prevention of various diseases and traits.
Predictive Accuracy
Genome Analysis Spin Off, in collaboration with Harokopeio University, has created a specialized innovative algorithm that allows the analysis of tens of thousands of polymorphisms in huge population samples, through big data analysis, based on international literature.
As a result, the PRS we are developing have up to 11,000 times more predictive power than earlier tests that looked at single polymorphisms.
Adaptation of Data to the Greek Population
The genetic background of various traits and diseases shows similarities between individuals in the same population. This is because the combinations of polymorphisms that affect their occurrence are found with similar frequency. In contrast, the combinations of these polymorphisms show variations between different peoples. Therefore, a genetic analysis with high predictive accuracy in Asians is not as accurate in Europeans, due to the interaction between different polymorphisms. It is therefore important that a PRS is tailored to the population it is testing.
In Genome Analysis we adapt and verify the global literature to the Greek population, based on data collected over the last 25 years by the research team of Professor G. Dedoussis at Harokopio University. Hence, we achieve the highest predictive ability in our PRSs.
Related Publications
Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments
George B. Busby, Scott Kulm, Alessandro Bolli, Jen Kintzle, Paolo Di Domenico & Giordano Bottà
Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults
Kafyra, M.; Kalafati, I.P.; Dimitriou, M.; Grigoriou, E.; Kokkinos, A.; Rallidis, L.; Marouli, E.; Dedoussis G. et al.
Quantifying the role of genetics via construction of polygenic risk scores (PRSs) is deemed a resourceful tool to enable and promote effective obesity prevention strategies…. read more
